Main Article Content
Multidrug resistant strain of S. aureus is the most common cause of life-threatening hospital- and community-acquired infections. Multidrug resistant S. aureus infections contribute to patients’ prolonged stay in the hospital, increase in total healthcare costs, morbidity, and mortality. This work was aimed at determining the occurrence and antibiotic susceptibility profile of Staphylococcus aureus isolated from some clinical samples (blood and urine) in General Hospital, Nasarawa, Nasarawa State, Nigeria. All the 14 samples (7 each for blood and urine) collected in this study yielded positive for S. aureus, which were identified by cultural appearances and confirmed using conventional biochemical tests.The antibiotic susceptibility profile of the isolates indicated that, majority of them exhibited high susceptibility to gentamycin (85.7%), ciprofloxacin (78.6%), vancomycin (71.4%), chloramphenicol (64.3%), teicoplanin (50.0%), and erythromycin (42.9%). All the 14 (100%) isolates tested showed resistance to oxacillin, amoxicillin (85.7%), and cefoxitin (78.6%).
Holmes A, Ganner M, McGuanes M, Pitt TL, Cookson BD. Staphylococcus aureus isolates carrying Panton-Valentein Leukocidin genes in England and Wales: Frequency, characterization, and association with clinical disease. Journal of Clinical Microbiology. 2005;43:2384-2390.
Oli AN, Nweke JN, Ugw MC, Anagu LO, Oli AH, Esimone CO. Knowledge and use of disinfection policy in some government hospitals in South-East, Nigeria. British Journal of Medicine and Medical Research. 2013;3(4):1097-1108(3):183- 87.
Nwankwo EO, Nasiru MS. Antibiotic sensitivity patterns of Staphylococcus aureus from clinical isolates in a tertiary health institution in Kano, North-Western Nigeria. Pan African Med. J. 2011;8:4.
National Bureau of Statistics. Federal republic of Nigeria, 2006 population census; 2009.
Japoni A, Alborzi A, Rasouli M, Pourabbas B. Modified DNA extraction for rapid PCR detection of methicillin resistant Staphylococci. Iran Biomed J. 2004; 8(3):161-165.
Clinical and Laboratory Standards Institute (CLSI). Performance standards for anti-microbial susceptibility testing. Eighteenth Information Supplement. 2012;28(1):34-52.
Garba S, Josiah AO, Busayo OO. Antibiotic susceptibility profile of Staphylococcus aureus rom clinical isolates in Zaria metropolis, Kaduna. Nigerian Journal of Pharmaceutical and Medical Research. 2017;2(2):116-120.
Aliyu Y, Jibril UY, Jibrin SM, Salawu EM. Occurrence and antibiotic resistant phenotypes of Staphylococcus aureus isolated from some hospital environments in Nasarawa Town, Nasarawa State, Nigeria. European Journal of Phar-maceutical and Medical Research. 2018; 5(11):20-26.
Joshua B, Owolabi R, Olorioke C. Prevalence and antimicrobial susceptibility profile of methicillin resistant Staphylococcus aureus and coagulase-negative staphylococci isolated from apparently healthy university students in Ota, Nigeria. Journal of Natural Sciences Research. 2015;5(24).
Newman MJ, Frimpong E, Asamoah-Adu A, Sampane-Donkor E. Resistance to antimicrobial drugs in Ghana. The Ghanaian – Dutch collaboration for Health Research and Development. 2006;1-6.
Levy S. Antibiotic resistance: Con-sequences of inaction. Clinical Infectious Diseases. 2001;33(3):S124-S129.