Haematological Indices and Predisposing Factors Associated with Tuberculosis at Federal Medical Center Owerri, Imo State, Nigeria

Main Article Content

Gideon I. A. Okoroiwu
Leticia I. Ebere

Abstract

Introduction: Tuberculosis (TB) is a chronic infectious disease caused by bacterium “Mycobacterium tuberculosis”. It is a systemic infection and has deleterious effect on both circulatory and respiratory systems, and thrives more in a society with little knowledge of its predisposing factors.

Aim of the Study: This study was carried out to identify the predisposing factors of tuberculosis and its effects on haematological indices of the positive patients at the Federal Medical Center, Owerri, Imo state, Nigeria.

Materials and Methods: The blood samples were analyzed manually for the indices while predisposing factors of Tuberculosis were obtained with the aid of a structured self-administered questionnair,these were administered simultaneously while the blood samples were been collected.

Results and Discussion: Results were considered to be statistically signifificant (P<0.05), (OR>1). Simple frequencies were also computed. The results revealed that Haemoglobin (P=0.001); Erythrocyte sedimentation rate (P=0.020); Neutrophils (P=0.002); Eosinophils (P=0.000); Monocytes (P=0.000); Platelets (P=0.001) of the Tuberculosis positive patients when compared with the controls, showed, statistically (P<0.05) significant haematological abnormalities. History of Tuberculosis in family (Odd ratio=9.3) and Alcoholism (OR=6.0) were significant predisposing factors of Tuberculosis. Other predisposing factors; smoking habits (OR=2.7), Educational status (OR=2.2), marital status (OR=1.3) were also associated with Tuberculosis infection, while employment status (OR=1.0) and socio-economic status (OR=0.1) were not. Tuberculosis infection in this study adversely affected Haemoglobin, Platelets, Erythrocyte sedimentation rate, Neutrophil, Eosinophil and Monocyte values, while family history of Tuberculosis and Alcoholism were significantly associated with the infection.

Conclusion: Quarrantine of Tuberculosis patients and creating more awareness on the predisposing factors of tuberculosis will help towards preventing, reducing and eliminating the disease.

Keywords:
Tuberculosis, predisposing factors, haematological indices, blood, patients.

Article Details

How to Cite
Okoroiwu, G. I. A., & Ebere, L. I. (2020). Haematological Indices and Predisposing Factors Associated with Tuberculosis at Federal Medical Center Owerri, Imo State, Nigeria. International Journal of TROPICAL DISEASE & Health, 40(2), 1-8. https://doi.org/10.9734/ijtdh/2019/v40i230223
Section
Original Research Article

References

Thomas MD. The history of tuberculosis. Respiratory Medicine. 2006;100(11):1862-1870.

Ananya M. History of tuberculosis; 2015.
Available:www.news-medical.net/health/history-of-Tuberculosis.aspx

Abraham OJ, Odiba PA, Haruna I, Yusuf D, Amodu AE, Yahaya-Oruma UA. Analysis of white blood cells in patients attending tuberculosis clinic at Holley Memorial Hospital. Ochadamu, OFU Local Government Area of Kogi State, Nigeria. Journal of Medical and Applied Biosciences. 2015;7(1):64-75.

Cauthen GM, Pio A, Ten DHG. Annual risk of tuberculosis infection. 1988 Bulletin of the WHO. 2002;80:503-511.

World Health Organization. Tuberculosis. Media Centre; 2015.
Available:www.who.int/mediacentre/factheets/fs104/en/

Padmanesan N, James W, Chandini RM, Dilip M. Risk factors for tuberculosis. Pulmonary Medicine. 2013;1-11.

Muhammad S, Ferhat A, Muhammad A, Mohammad A, Niamatuilahakakar ZA. Haematological profile and risk factors associated with pulmonary tuberculosis patients in Quetta, Pakistan. Pak. J. Med. Sci. 2014;30(1):36-40.

Nigeria TB Factsheet. Economic section. United States Embassy in Nigeria; 2012.
Available:Photos.state.gov./libraries/Nigeria/487468/pdfs/JanuaryTuberculosis-Factsheet.pdf

Guardian Newspaper. New cases of tuberculosis in Nigeria; 2015.
Available:www.ngrguardiannews.com/2015/03/600,000-new-cases-of-tb-in-nigeria-by-agency/

Naing L, Winn T, Rusli BN. Practical issues in calculating sample size. Archives of Orofacial Sciences. 2006;1:9-14.

Ochei J, Kolhatkar A. Medical laboratory: Theory and practice. 9th Reprint; Tata McGraw-Hill Pub.co Ltd. 2008;273-283.

Baker FJ, Silverton RE, Pallister CJ. Introduction to medical laboratory technology. 7th, Edition, Arnold, Bounty Press Ltd. 2011;354-372.

Ferrara G, Murray M, Winthrop K, Cantis R, Sotqiu G, Migliori GB. Risk factors associated with pulmonary tuberculosis: Smoking, diabetes and anti-TNF& drugs. Curr Opin Pulm Med. 2012;18(3):233-40.

Houtmeyers H, Gosselink R, Gayan-Ramirez G, Decramer M. Regulation of mucocilliary clearance in health and disease. European Respiratory Journal. 1999;13(5):1177-1188.

Sopori M, Wang H. Effects of cigarette smoke on the immune system. Nature. 2003;421(6921):384-388.

Wang H, Yu M, Ochani M. Nicotinic acetylcholine receptor & 7 subunits as an essential regulator of inflammation. Nature. 2003;421(6921):384-388.

Arcari L, Benowitz NL. Cigarette smoking and infection. Archives of Internal Medicine. 2004;164(20):2206-2216.

Moshin SS, Hafiz AMF, Waqas AB, RaziaIftikhar NK. Environmental and host-related factors predisposing to Tuberculosis in Karachi: A cross-sectional study. Journal of Pioneering Medical Sciences. 2011;1(1):13-18.

Joshi R, Reingold AL, Menzies D, Pai M. Tuberculosis among health-care workrs in low and middle income countries: A systemic review. PLOS Medicine. 2006;3(12):e494.

Bolette S, AaseBengaard A, Mada M, Jan W, Mikael A, Robert JB. Risk factors for Mycobacterium tuberculosis infection among children in Greenland. Bulletin of the World Health Organization. 2011;89:741-748E.

Szabo G. Alcohols contribution to compromised immunity. Alcohol Research and Health. 1997;21(1):30-38.

Lonnroth K, Jaramillo E, Williams BG, Dye C, Raviglione M. Drivers of tuberculosis epidemics: The role of risk factors and social determinants. Social Science and Medicine. 2009;68(12):2240-2290.

Muniyandi M, Ramachandran R, Gopi PG. The prevalence of tuberculosis in different economic strata: A community survey from South India. Inter. Jour. Tuberculosis and Lung Disease. 2007;11(9):1042-1045.

Abba K, Sudarsanam TD, Grobler L, Volmink J. Nutritional supplements for people being treated for active tuber-culosis. Cochrane Database of Systematic Review. 2008;4. ID: CD006086.

Grady O, Maeurer JM, Afum R, Abubakar I, Mwaba P. Tuberculosis in prisons: Anatomy of global neglect. European Respiratory Journal. 2011;38(4):752-754.