Evaluation of Anti-urolithiasis Activity by Nucleation Assay

Siddhartha Lolla

Department of Pharmacology, Pulla Reddy Institute of Pharmacy, Jawaharlal Nehru Technological University, Dundigal, Hyderabad, Telangana, 500043, India.

Harika Peddinti

Department of Pharmacology, Pulla Reddy Institute of Pharmacy, Jawaharlal Nehru Technological University, Dundigal, Hyderabad, Telangana, 500043, India.

Sravanthi Gojuvaka

Department of Pharmacology, Pulla Reddy Institute of Pharmacy, Jawaharlal Nehru Technological University, Dundigal, Hyderabad, Telangana, 500043, India.

Samrin Saba

Department of Pharmacology, Pulla Reddy Institute of Pharmacy, Jawaharlal Nehru Technological University, Dundigal, Hyderabad, Telangana, 500043, India.

Uma Devi Dasari

Department of Pharmacology, Pulla Reddy Institute of Pharmacy, Jawaharlal Nehru Technological University, Dundigal, Hyderabad, Telangana, 500043, India.

Madhavi Pillalamarri *

Department of Pharmacology, Pulla Reddy Institute of Pharmacy, Jawaharlal Nehru Technological University, Dundigal, Hyderabad, Telangana, 500043, India.

*Author to whom correspondence should be addressed.


Abstract

Many causes, including the efficiency of plant medicines and their lower side effects when compared to contemporary medications, have contributed to the current rebirth of plant therapies. Given the current situation, basic scientific research on the therapeutic herbs utilized in indigenous systems is urgently needed. The purpose of this review is to provide information on current developments in the study of medicinal plants recognized for their antiurolithiatic properties. This could assist researchers in determining and creating suitable lead compounds or plant products that are advantageous in the treatment of urolithiasis. A series of physicochemical processes, including supersaturation, nucleation, growth, aggregation, and retention inside the kidneys, combine to form kidney stones. In developed nations, 10–12% of people suffer from urinary stones. There are very few places in the world where stone disease is uncommon, such as Germany and the coastal regions of Japan. Thus, the purpose of this review is to provide information about current developments in the study of medicinal plants recognized for their antiurolithiatic properties. Researchers may find this article useful in identifying the primary compounds or herbal products that exhibit urolithiatic activity.

Keywords: Kidney stones, calcium oxalate crystals, nucleation, cystone


How to Cite

Lolla , S., Peddinti , H., Gojuvaka, S., Saba , S., Dasari , U. D., & Pillalamarri , M. (2024). Evaluation of Anti-urolithiasis Activity by Nucleation Assay. International Journal of TROPICAL DISEASE & Health, 45(6), 13–20. https://doi.org/10.9734/ijtdh/2024/v45i61535

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References

Shelke T, Wayal S, Gunjegaokar S, Gaikwad S, Shirsath A, Hadke S. An overview on Indian medicinal plants with antiurolithiatic activity. J. Pharm. Res. Clin. Pract. 2014, Jul;4:33-40.

Yadav RD, Jain SK, Alok S, Mahor A, Bharti JP, Jaiswal M. Herbal plants used in the treatment of urolithiasis: A review. IJPSR. 2011, Jun 1;2(6):1412-20.

Khan F, Haider MF, Singh MK, Sharma P, Kumar T, Neda EN. A comprehensive review on kidney stones, its diagnosis and treatment with allopathic and ayurvedic medicines. Urol Nephrol Open Access J. 2019, Aug;7(4):69-74.

Ahmed MM, Singh KP. Traditional knowledge of kidney stones treatment by Muslim Maiba (herbalists) of Manipur, India. Notulae Scientia Biologicae. 2011, May 16;3(2):12-5.

Arya P, Pandey S, Verma V. Kidney stone formation and use of medicinal plants as antiurolithiatic agents. Universal Journal of Pharmaceutical Research. 2017;2(4): 42-8.

KVSRG P, Sujatha D, Bharathi K. Herbal drugs in urolithiasis-A review. Pharmacog Rev. 2007, Jan;1(1):175-8.

Ram J, Moteriya P, Chanda S. An overview of some promising medicinal plants with In vitro anti-urolithiatic activity. IOSR J. Pharm. 2015;5:23-8.

Vargas SR, Perez GRM, Perez GS, Zavala SMA, Perez GC. Antiurolithiatic activity of Raphanus sativus aqueous extract on rats. Journal of Ethnopharmacology. 1999, Dec 15;68(1-3):335-8.

Baheti DG, Kadam SS. Antiurolithiatic activity of some traditional medicinal plants against calcium oxalate induced urolithiasis in rats. International Journal of Pharmaceutical, Chemical & Biological Sciences. 2013, Oct 1;3(4).

Bahmani M, Baharvand-Ahmadi B, Tajeddini P, Rafieian-Kopaei M, Naghdi N. Identification of medicinal plants for the treatment of kidney and urinary stones. Journal of Renal Injury Prevention. 2016;5(3):129.

Yadav A, Das R, Mehta DK. Benefaction of herbals in the management of urolithiasis. Current Traditional Medicine. 2021, Aug 1;7(4):541-51.

Kasote DM, Jagtap SD, Thapa D, Khyade MS, Russell WR. Herbal remedies for urinary stones used in India and China: A review. Journal of Ethnopharmacology. 2017, May 5;203:55-68.

Shukla AK, Shukla S, Garg A, Garg S. A review on anti-urolithiatic activity of herbal folk plants. Asian Journal of Biomaterial Research. 2017;3(2):1-1.

Patle A, Hatware KV, Patil K, Sharma S, Gupta G. Role of herbal medicine in the Management of Urolithiasis—A Review for future perspectives. Journal of Environmental Pathology, Toxicology and Oncology. 2019;38.

Bar FA, Foudah A, Majrashi A, Al-Dossery F, Galala A. In-vitro evaluation of some traditional medicinal plants on calcium oxalate urolithiasis. Emirates Journal of Food and Agriculture; 2021.

Kant R, Singh TG, Singh S. Mechanistic approach to herbal formulations used for urolithiasis treatment. Obesity Medicine. 2020, Sep 1;19:100266.

Rasool M, Mousa T, Alhamadani H, Ismael A. Therapeutic potential of medicinal plants for the management of renal stones: A review. Baghdad Journal of Biochemistry and Applied Biological Sciences. 2022, Jun 30;3(02):69- 98.

Raj S, Rajan MS, Ramasamy S, Goldy RI, Ariyamuthu R, Sudhagar M, Gandhi S, Shoba P, Gurusamy M. An In vitro Anti-urolithiasis activity of a herbal formulation: Spinacia oleracea L. and Coriandrum sativum L. Clinical Complementary Medicine and Pharmacology. 2024, Mar 1; 4(1):100124.

Gaybullaev A, Kariev S. Phytotherapy of calcium urolithiasis with extracts of medicinal plants: Changes of diuresis, urine pH and crystalluria. Applied Technologies & Innovations. 2012, Jun 1; 7(2).

Tiwari A, Soni V, Londhe V, Bhandarkar A, Bandawane D, Nipate SO. An overview on potent indigenous herbs for urinary tract infirmity: Urolithiasis. Asian J Pharm Clin Res. 2012;5(1):7-12.

Aryal S, Kuwar P, Thapa C. Antiurolithiatic activity of selected plants extracts against calcium oxalate crystals. Journal of Medicinal Plants Research. 2021, Apr 30;15(4):172-7.

Yasir F, Waqar MA. Effect of indigenous plant extracts on calcium oxalate crystallization having a role in urolithiasis. Urological Research. 2011, Oct;39:345-50.

Dinnimath BM, Jalalpure SS, Patil UK. Antiurolithiatic activity of natural constituents isolated from Aerva lanata. Journal of Ayurveda and Integrative Medicine. 2017, Oct 1;8(4):226-32.

Saxena N, Argal A. Study of antiurolithiatic activity of a formulated herbal suspension. Herba Polonica. 2015;61(2):41-9.

Santhanam A. Antiurolithic activity of aqueous extracts of leaves of capparis moonii in ethylene glycol-induced urolithiasis model using rats (Doctoral dissertation, JKK Nattraja College of Pharmacy, Kumarapalayam).

Beto JA. Herbal use in the nutrition management of kidney stones. Nutritional and Medical Management of Kidney Stones. 2019;255-60.

Kültür Ş, Gürdal B, Sari A, Melikoğlu G. Traditional herbal remedies used in kidney diseases in Turkey: An overview. Turkish Journal of Botany. 2021;45(4):269-87.

Kumar A. Evaluation of antiurolithiatic activity of ethanolic extract of seed of Caesalpinia bonducella.

Raikwar D, Patel MK. Role of herbal medicines in the treatment of Kidney stone: A brief review. Adv Pharm J. 2022;7(5):149-54.

Boim MA, Heilberg IP, Schor N. Phyllanthus niruri as a promising alternative treatment for nephrolithiasis. International braz j urol. 2010;36 :657-64.