Comparative Study on Anti-Diabetic Activity of Momordica charantia and Psidium guajava

Pillalamarri Madhavi *

Department of Pharmacology, Pulla Reddy Institute of Pharmacy, Hyderabad-502313, India.

D. Niharika

Department of Pharmacology, Pulla Reddy Institute of Pharmacy, Hyderabad-502313, India.

B. Niharika

Department of Pharmacology, Pulla Reddy Institute of Pharmacy, Hyderabad-502313, India.

Marfat Ali

Department of Pharmacology, Pulla Reddy Institute of Pharmacy, Hyderabad-502313, India.

Saidul Islam

Department of Pharmacology, Pulla Reddy Institute of Pharmacy, Hyderabad-502313, India.

C. Ramya

Department of Pharmacology, Pulla Reddy Institute of Pharmacy, Hyderabad-502313, India.

*Author to whom correspondence should be addressed.


Abstract

Diabetes is a metabolic disease characterised by decreased insulin signalling and persistent hyperglycaemia. The most frequent progression of diabetes is known as diabetes mellitus which is defined as persistent hyperglycaemia brought on by either peripheral insulin resistance or impaired pancreatic β cell production of insulin. This condition is caused by the disruptions in the digestion of carbohydrates, fats and proteins which are caused by defects in the production, release and regulation of insulin. The breakdown of carbohydrates is significantly aided by the intestinal digestive enzymes α-glucosidase and α-amylase. One type of antidiabetic treatment is to lower the blood glucose levels after a meal by blocking the enzymes α-glucosidase and α-amylase. This could be a key tactic in blood glucose control. When compared to other commercial pharmaceuticals used to treat diabetes, herbal treatments are thought to be more in harmony with the human body and to have less harmful side effects. This herbal remedy is reasonably priced as well. The aim of the  current study is to compare the anti- diabetic activity of the methanolic extracts of Momordica charantia and Psidium guajava. The methods used in the determination of invitro antidiabetic activity are alpha amylase and alpha glucosidase inhibitory assays. In the current study, when compared the individual inhibition activity of Momordica charantia and Psidium guajava on the intestinal enzymes (alpha amylase and alpha glucosidase), Momordica charantia has the highest inhibition that is 79.83% at 0.8 mL concentration while the Psidium guajava has shown only 70.58% inhibition at 0.8 mL concentration. Which suggests that the presence of bio active compounds may be responsible for the plants many medicinal uses, including the treatment of diabetes.

Keywords: Diabetes mellitus, hyperglycaemia, insulin, resistance, α-glucosidase, α-amylase, herbal remedy


How to Cite

Madhavi , P., Niharika, D., Niharika , B., Ali , M., Islam , S., & Ramya , C. (2024). Comparative Study on Anti-Diabetic Activity of Momordica charantia and Psidium guajava. International Journal of TROPICAL DISEASE & Health, 45(6), 133–138. https://doi.org/10.9734/ijtdh/2024/v45i61546

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References

Díaz-de-Cerio E, Verardo V, Gómez-Caravaca AM, Fernández-Gutiérrez A, Segura-Carretero A. Exploratory characterization of phenolic compounds with demonstrated anti-diabetic activity in guava leaves at different Oxidation States. International Journal of Molecular Sciences. 2016;17(5):699.

Wadkar KA, Magdum CS, Patil SS, Naikwade NS. Antidiabetic potential and Indian medicinal plants. Journal of herbal medicine and toxicology. 2008;2(1): 45-50.

Patel DK, Kumar R, Laloo D, Hemalatha S. Diabetes mellitus: an overview on its pharmacological aspects and reported medicinal plants having antidiabetic activity. Asian Pacific Journal of Tropical Biomedicine. 2012;2(5):411-20..

Kumar BD, Mitra A, Manjunatha M. In vitro and in vivo studies of antidiabetic Indian medicinal plants: A review. Journal of Herbal Medicine and Toxicology. 2009; 3(2):9-14.

Arumugam G, Manjula P, Paari N. A review: Anti diabetic medicinal plants used for diabetes mellitus. Journal of Acute Disease. 2013;2(3):196-200.

Ponnusamy S, Ravindran R, Zinjarde S, Bhargava S, Ravi Kumar A. Evaluation of traditional Indian antidiabetic medicinal plants for human pancreatic amylase inhibitory effect In vitro. Evidence-Based Complementary and Alternative Medicine. 2010;2011.

Kifle ZD, Abdelwuhab M, Melak AD, Meseret T, Adugna M. Pharmacological evaluation of medicinal plants with antidiabetic activities in Ethiopia: A review. Metabolism open. 2022;13:100174.

Pari L, Hypoglicaemic SG. antihyperglyceamic effect of Syzygium cumini Bark in etreptozotocin induced diabetic Rast. J. Pharmacol. Toxicol. 2008; 3(1):1-0.

Swathika Kothmiri. Evaluation of anti-diabetic activity by using traditional medicinal plants. European chemical bulletin. 2023;12(5):01-08.

Budrat P, Shotipruk A. Extraction of phenolic compounds from fruits of bitter melon (Momordica charantia) with subcritical water extraction and antioxidant activities of these extracts. Chiang Mai J Sci. 2008;35(1):123-30.

Lee Y, Kim S, Yang B, Lim C, Kim JH, Kim H, Cho S. Anti-inflammatory effects of Brassica oleracea Var. capitata L.(Cabbage) methanol extract in mice with contact dermatitis. Pharmacognosy Magazine. 2018;14(54): 174

Yuguda YM. Production and in vitro studies of Bitter Gourd (Momodica charantia) seed protein hydrolysates with antidiabetic activity. GSC Biological and Pharmaceutical Sciences. 2023;22(2):222-33.

Hamed MM. Antidiabetic activity of medicinal plants. International. Journal of Pharmaceutical Sciences Review Research. 2018;51(1):151-65.

Manikandan R, Anand AV, Muthumani GD. Phytochemical and in vitro anti-diabetic activity of methanolic extract of Psidium guajava leaves. International Journal of Current Microbiology and Applied Sciences. 2013;2(2):15-9.