Awareness and Factors Associated with TB-LAMP Positivity among Patients with Presumptive Pulmonary Tuberculosis in Ibadan, Nigeria
Bamidele Wemimo Taiwo *
Department of Medical Laboratory Science, Faculty of Medical Laboratory Science, Lead City University, Ibadan, Oyo State, Nigeria.
Toyosi Raheem
Department of Medical Laboratory Science, Faculty of Medical Laboratory Science, Lead City University, Ibadan, Oyo State, Nigeria and Molecular Biology and Biotechnology Nigeria Institute of Medical Research, Yaba, Lagos, Nigeria.
Adesola Oniye
Department of Medical Laboratory Science, Faculty of Medical Laboratory Science, Lead City University, Ibadan, Oyo State, Nigeria.
Bamidele Bukunmi Kehinde
Department of Medical Laboratory Science, Faculty of Medical Laboratory Science, Lead City University, Ibadan, Oyo State, Nigeria.
Amusan Festus Olatubosun
Department of Medical Laboratory Science, Faculty of Medical Laboratory Science, Lead City University, Ibadan, Oyo State, Nigeria.
Adeniran Ramoni
Department of Medical Laboratory Science, Faculty of Medical Laboratory Science, Lead City University, Ibadan, Oyo State, Nigeria.
T. Adefila Samuel
Department of Medical Laboratory Science, Faculty of Medical Laboratory Science, Lead City University, Ibadan, Oyo State, Nigeria and Department of Medical laboratory Science, Faculty of Basic Medical Science, Adeleke University, Ede, Osun State, Nigeria.
*Author to whom correspondence should be addressed.
Abstract
Aims: To assess awareness of tuberculosis (TB) and the factors associated with TB-LAMP positivity among patients with presumptive pulmonary tuberculosis (PTB) at a specialised chest hospital in Ibadan, Nigeria.
Study Design: Hospital-based cross-sectional study.
Place and Duration of Study: Chest Hospital, Jericho, Ibadan, Oyo State, Nigeria, between October 2025 and July 2026.
Methodology: A total of 157 patients with presumptive PTB were selected by systematic sampling and interviewed using a structured questionnaire. Awareness was scored from eight items (0-8); scores below the sample mean were classified as poor awareness. TB-LAMP results were abstracted from hospital laboratory records and were used as the study outcome variable. Associations were assessed with the chi-square test and binary logistic regression (odds ratios with 95% confidence intervals); p < 0.05 was significant.
Results: Of 157 respondents, 87 (55.4%) had poor overall awareness (mean score 3.45 ± 1.36 of 8) and 85 (54.1%) had ever heard of TB. TB-LAMP was positive in 52 (33.1%). Poor awareness (crude OR 0.72, 95% CI 0.37-1.41) and having heard of TB (OR 1.57, 95% CI 0.80-3.09) were not associated with TB-LAMP positivity. In multivariable analysis, being a farmer, student or unemployed was independently associated with positivity (adjusted OR 2.57, 95% CI 1.25-5.31; exploratory grouping). The single-item awareness measure did not differ by sex, marital status, education or religion (all p > 0.05).
Conclusion: Awareness of PTB was inadequate among patients with presumptive PTB but was not associated with TB-LAMP positivity. Occupational grouping (farmer, student or unemployed) was the only independently associated factor; this exploratory finding requires confirmation. Routine, structured TB education at the point of care is recommended.
Keywords: Pulmonary tuberculosis, tuberculosis awareness, TB-LAMP, presumptive tuberculosis, molecular diagnosis, health education