Blood Cell Profiling of Malaria Patients Attending Gaya General Hospital, Kano State, Northern Nigeria

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M. U. Ali
A. A. Panda
S. M. Yahaya
U. A. Umar
M. S. Inuwa
Y. S. Ajingi
S. Idris


Background: Changes in blood cell profile were common findings in malaria. In the rural community of Kano State, Nigeria, information on haematological changes in human malaria was scanty in spite of their role in the pathophysiology of malaria. This cross-sectional study was undertaken to determine blood cell profiles in malaria patients attending a rural hospital in malaria-endemic region.

Methods: Blood samples (3 ml each) were collected in EDTA-containers from 150 randomly selected outpatients attending Gaya General Hospital, screened for malaria using RDT kit (CareStart Malaria HRP 2, Access Bio Inc., USA) based on Histidine-rich protein 2 (PfHRP-2), and blood cell profiles determined using automated Sysmex haematologic analyser. Data on socio-demographics and medical history related to the study objectives, such as taking antimalarial regimen and/or haematinic, and direct involvement in blood transfusion, were obtained by questionnaire administration supplemented with oral interview.

Findings: The study revealed a malaria prevalence of 67.33%, with highest in 11-20years (80.95%) and lowest (55.00%) in 1-10years age-groups; slightly higher in females (68.25%) than in males (66.67%) without significant difference (P<0.05). For blood parameters, malaria positive patients have a significantly lower mean PCV of 32.2% as compared to 38.18% obtained for malaria negative patients (P<0.05). The mean Hb was 10.76±2.27g/dL and 12.65±2.38g/dL (P<0.05), while WBC revealed 6.91×109/L and 6.56×109/L in malaria positive and negative patients, respectively. Platelet counts recorded 179.24×109/L and 230.47×109/L (P<0.05). Socio-demographic factors such as level of education, occupation and marital status did not significantly influence malaria prevalence.

Interpretation: Low PCV and Hb in malaria patients indicate mild anaemia due to malaria-related haemolysis. The occurrence of thrombocytopenia may be due to other underlying pathology as further studies with larger sample size are needed to ascertain the cause of low platelet counts in malaria patients in the study area.

Malaria prevalence, blood parameters, anaemia, rural community, thrombocytopenia.

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How to Cite
Ali, M. U., Panda, A. A., Yahaya, S. M., Umar, U. A., Inuwa, M. S., Ajingi, Y. S., & Idris, S. (2019). Blood Cell Profiling of Malaria Patients Attending Gaya General Hospital, Kano State, Northern Nigeria. International Journal of TROPICAL DISEASE & Health, 39(2), 1-11.
Original Research Article


WHO. World Malaria Report 2014 Geneva, Switzerland: World Health Organisation; 2014.

Dawaki S, Hesham MA, Init T, Jamaih I, Wahib MA, Awatif MA, Hany S, Fatin NE, Ado UA, Yelwa SI, Ahmed A, Al-areeqi MA, Subramaniam LR, Nabil AN, and Yee-ling L.. Is Nigeria winning the battle against malaria? Prevalence, risk factors and KAP assessment among Hausa communities in Kano State. Malaria Journal; 2016.

Caraballo H. Emergency department management of mosquito-borne illness: Malaria, dengue, and west nile virus. Emergency Medicine Practice. 2014;16(5).

Sabbatani S, Fiorino S, Manfredi R. The emerging of the fifth malaria parasite (Plasmodium knowlesi): A public health concern? Braz. J. Infect. Dis. 2010;4(3): 299-309.

WHO. 2008;10.
[Retrieved 2009-08-17]

Maina RN, Walsh D, Gaddy C, Hongo G, Waitumbi J, Otieno L, Jones D, Ogutu BR.. Impact of Plasmodium falciparum infection on haematological parameters in children living in Western Kenya. Malaria Journal. 2010;9(suppl.3):S4.

Petel U, Gandhi G, Friedman S. Thrombocytopenia in plasmodium malaria. Am J Trop Med Hyg. 2004;59:859-865.

National Population Commission. Population distribution by Sex, State, LGAs and Senatorial district: 2006 Census Priority Tables. 2006;3.

Cheesbrough M. District Laboratory Practice in in Tropical Countries. Part 2. Cambridge University Press. 2006;296-299.

Greenwood D, Barer M, Slack R , Irving W Medical Microbiology, 18th edition, China. 2012;642.

WHO. World Malaria Report 2011, WHO Global Malaria Programme; 2011.

Aina OO, Agomo CO, Olukosi YA, Okoh HI, Iwalokun BA, Egbuna KN, Orok AB, Ajibaye O, Enya VNV, Akindele SK, Akinyele MO and Agomo PU. Malariometric survey of Ibeshe communitu in Ikorodu, Lagos State: Dry season. Malaria Research and Treatment. 2013:1-7.

WHO: Global Malaria Control and Strategy. WHO Regional Office for South-East Asia. 2003;2:1-25.

Thomas S, Ravishankaran S, Asokan A, Justin NAJA, Kalsingh TMJ, Mathai MT, Valecha N, Eapen A. Socio-demographic and household attributes may not necessarily influence malaria: Evidence from a cross sectional study of households in an urban slum setting of Chennai, India. Malaria Journal. 2018;17:4.

Paul E, Msengwa AS. Prevalence and socio-demographic factors associated with malaria infection among children under five years in Tanzania. Journal of Public Health and Epidemiology. 2018;10(11):387-394.

Price RN, Simpson JA, Nosten F, Luxemburger C, Hkirjaroen L, Terkuile F, Chongsuphajaisiddhi T, White NJ. Factors contributing to anaemia after uncomplicated falciparum malaria. Am J Trp Med Hyg. 2001;65:614-622.

Facer CA. Hematological aspect of malaria In: Infection and Hematology. Oxford Butterworth Heinemann Ltd. 1994:259-94.

Beals PF. Anemia in malaria control: A practical approach. Ann Trop Med Parasitol. 1997;91:713-718.

Hill AVS, Allsop CEM, Kwiatkowski D et al.. Common West African HLA antigens are associated with protection from severe malaria. Nature. 1991;352:595-600.

Okafor FU, Oko-ose JN. Prevalence of malaria infection among children aged six months to eleven years (6months –11years) in a tertiary institution in Benin City, Nigeria. Global Advanced Resource Journal of Medicine and Medical Sciences. 2012;1: 273-279.

Wickramasinghe SN, Abdulla SH. Blood and Bone Marrow changes in Malaria. Baillieres Best Pract Res Clin Haematol. 2001;3:277-299.

Bashawri LA, Mandil AA, Bahnassy AA, Ahmed MA. Malaria: Hematological aspects. Ann Saudi Med. 2002;22:372-376.

WHO.The global Malaria Situation: Current tools for prevention and control. Global Fund to fight AIDS, Tuberculosis, and Malaria. 55 World Assembly, WHO Document. May. A551; 2002.

Menendez C, Fleming AF, Alonso PL Malaria-related anemia. Parasitol Today. 2000;16:469-476.

Jootar S, Chaisiripoomkere W, Pholvicha P, Leelasiri A, Prayoonwiwat W, Mongkonsvitragoon W, and Srichaikul T. Suppression of erythroid progenitor cells during Malarial Infection in Thai adults caused by serum inhibitor. Clin. Lab. Haematol. 1993;15:87.

Modiano D, Sirima BS, Konaté A, Sanou I, Sawadogo A. Leucocytosis in severe malaria, Transactions of the Royal Society of Tropical Medicine and Hygiene. 2001; 95(2):175-176.

McKenzie FE, Smith DL, Omeara WP, Riley EM. Strain theory of malaria: The first 50 years. Adv. Parasitol. 2008;66:1-46.

Taylor H, Widjaja H, Basri et al. Changes in the total leukocyte and platelet counts in Papuan and non-Papuan adults from northeast Papua infected with acute Plasmodium vivax or uncomplicated Plasmodium falciparum malaria, Malaria Journal. 2008;7:259.

Tangpukdee N, H.-S. Yew, S. Krudsood et al. Dynamic changes in white blood cell counts in uncomplicated Plasmodium falciparum and P. vivax malaria, Parasitology International. 2008;57(4):490 494.

Lathia TB, Joshi R. Can haematological parameters discriminate malaria from nonmalarious acute febrile illness in the tropics? Indian J Med Sci, 2004;58:239 244.

Rodriguez-Morales AJ, Sanchez E, Vargas M, Piccolo C, Colina R, Arria M, Franco-Paredes C. Occurrence of thrombocytopenia in Plasmodium vivax malaria. Clin Infect Dis. 2005;41:130- 131.

Jamison DT, Feachem RG, Makgoba MW Disease and mortality in sub-Saharan Africa, 2nd edition, Washington DC; 2006.

Pain A, Feguson DJ, Kai O, Urban BC, Lowe B, Marsh K et al.. Platelet-mediated clumping of Plasmodium falciparum-infected erythrocytes is a common adhesive phenotype and is associated with sever Malaria. Proc. Natl Acad Sci USA. 2001;98:1805-1810.

Clark IA, Chaudhri G. Tumour necrosis factor may contribute to the anaemia of malaria by causing dyserythropoiesis and erythrophagocytosis. Brit J Haematol, 1998; 70:99-103.