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Background: The incidence of schistosomiasis in Ghana and more specifically in the Asuogyaman District had become a noticeable record following the creation of the Akosombo Dam in the early 1960s. This has inevitably since placed an enormous burden on the health service delivery systems in the geographical area. Mass Drug Administration (MDA) of Praziquantel has been used worldwide as a preventive and treatment intervention measure for the disease, and the study area is no exception. The study, therefore, aimed to assess the impact of MDA on the prevalence and associated risk factors of schistosomiasis in eight (8) selected riverine communities within the district.
Methods: A descriptive retrospective cross-sectional study was conducted involving 896 respondents with ages ranging from 2 to 82 years and a mean age of 17±13.78 years. Data were obtained from the Volta River Authority (VRA) Public Health and Environmental Department. Pearson’s chi-square tests and logistic regression models were used to assess the association and predict the relationship between variables.
Findings: Out of the 896 respondents, 93 (10.4 %) tested positive for Schistosoma haematobium. Proportionally, the Nyameben community had a high prevalence of 25.8% while Mami-Waterkope, and Mangoase both had a low prevalence of 3.2 %. The average uptake of Praziquantel was 41% across the study area. From the bivariate analysis, the respondents’ community of residence was noted as the only statistically significant variable contributing to infection. Respondents aged 13-39 were 1.68 times more likely to be infected compared to their younger counterparts after controlling for all other covariates in the predictive model.
Conclusion: Mass Drug Administration had a tremendous effect on reducing the prevalence of urinary schistosomiasis to the present level of 10.4%. However, some “hotspots” like the Nyameben community will require special attention to reduce the high prevalence disease rate. Communities with low uptake of Praziquantel had a relatively high prevalence of schistosomiasis.
Joanne P Webster, David H Molyneux, Peter J Hotez, Alan Fenwick. ‘The contribution of mass drug administration to global health : Past, present and future. Philosophical Transaction of Royal Society B. 2014:369. Available:https://doi.org/10.1098/rstb.2013.0434
Bodimeade C, Marks M, Mabey D. Neglected tropical diseases: elimination and eradication. Clinical Medicine. 2019;19(2):157-160. Available:https://doi.org/10.7861/clinmedicine.19-2-157
Adenowo AF, Oyinloye BE, Ogunyinka BI, Kappo AP. ‘Impact of human schistosomiasis in sub-Saharan Africa’, The Brazilian Journal of Infectious Diseases. 2015;1(92):196–205. Available:https://doi.org/10.1016/j.bjid.2014.11.004.
Barakat RMR. ‘Epidemiology of Schistosomiasis in Egypt: Travel through Time: Review’, Journal of Advanced Research, 2013;4:425–432. Available:https://doi.org/10.1016/j.jare.2012.07.003
Di Bella S, Riccardi N, Giacobbe DR, Luzzati R. History of schistosomiasis (bilharziasis) in humans: from Egyptian medical papyri to molecular biology on mummies. Pathogens and Global Health. 2018;112(5):268-273. Available:https://doi.org/10.1080/20477724.2018.1495357.
Jordan P. Schistosomiasis: The St Lucia Project - Peter Jordan - Google Books, Cambridge: Cambridge University Press; 1985. Available:https://doi.org/10.1017/S0025727300045865.
Droz J. Tropical Hemato-Oncology - Google Books; 2015. Available:https://books.google.com.gh/books/about/Tropical_Hemato_Oncology.html?id=g1UwCgAAQBAJ&redir_esc=y.
Schistosomiasis [InternetAvailable: https://www.who.int/news-room/fact-sheets/detail/schistosomiasis. [cited 2020 Mar 14].
Jamieson BGM. Schistosoma : Biology, pathology, and control; 2017. ISBN:9781498744256. Available:https://www.crcpress.com/Schistosoma-Biology-Pathology-and-Control/Jamieson/p/book/9781498744256
Salwa D, Hesham MA, Init I, Jamaiah I, Awatif MA, Abdulhamid A, Hany S, Wahib MA, MAA, Fatin NE, Nabil Ahmed N, Johari S. ‘Prevalence and risk factors of schistosomiasis among Hausa communities in Kano State, Nigeria’. Rev. Inst. Med. Trop. S. Paulo. 2016;56. Available:https://doi.org/10.1590/S1678-9946201658054
WHO. Crossing the billion. Lymphatic filariasis, onchocerciasis, schistosomiasis, soil-transmitted helminthiases and trachoma: Preventive chemotherapy for neglected tropical diseases; 2017. Available:https://www.who.int/neglected_diseases/resources/9789240696471/en/
Wikipedia; 2018. Available:https://en.wikipedia.org/wiki/Schistosoma_mansoni.
Manuela Ciddio Lorenzo Mari, Susanne H Sokolow, Giulio A De Leo, Renato Casagrandiand MarinoGatto. The spatial spread of Schistosomiasis: A multidimensional network model applied to Saint-Louis region, Senegal. Advances in Water Resources. 2016;108:406-415. Available:https://doi.org/10.1016/j.advwatres.2016.10.012
WHO. ‘WHO | Epidemiological situation’, WHO. World Health Organization; 2016. Available:https://www.who.int/gho/publications/world_health_statistics/2016/Annex_B/en/
Turner HC, Truscott JE, Hollingsworth, TD. Cost and cost-effectiveness of soil-transmitted helminth treatment programmes: Systematic review and research needs. Parasites Vectors. 2015;8:355 Available:https://doi.org/10.1186/s13071-015-0885-3
Crompton DWT. (David WT, WHO). Preventive chemotherapy in human helminthiasis : Coordinated use of anthelminthic drugs in control interventions : A manual for health professionals and programme managers. World Health Organization; 2006. Available:https://apps.who.int/iris/bitstream/handle/10665/43545/9241547103_eng.pdf?sequence=1
Joanne P Webster, David H. Molyneux, Peter J Hotez, Alan Fenwick. ‘The contribution of mass drug administration to global health: past, present and future’. Philosophical Transaction of Royal Society-Biological Sciences. 2014;19:369. Available:https://doi.org/10.1098/rstb.2013.0434
Cunningham LJ, Campbell SJ, Armoo S, Koukounari A, Watson V, Selormey P, Stothard JR, Idun B, Asiedu M, Ashong Y, Adams ER, Osei-Atweneboana MY. Assessing expanded community-wide treatment for schistosomiasis: Baseline infection status and self-reported risk factors in three communities from the Greater Accra Region, Ghana. PLoS Neglected Tropical Diseases. 2020;14(4):e0007973. Available:https://doi.org/10.1371/journal.pntd.0007973
Population and Housing Census Asuogyaman District; 2010). Available:https://new-ndpc static1.s3.amazonaws.com/CACHES/PUBLICATIONS/2016/06/06/Asuogyaman+2010PHC.pdf
Survey Monkey. Sample Size Calculator: Understanding Sample Sizes | Survey Monkey; 2018. Available:https://www.surveymonkey.com/mp/sample-size-calculator/
Susanne S. ‘History of Schistosomiasis Control in Ghana’; 2015. Available:https://schisto.stanford.edu/pdf/Ghana.pdf
Patience B Tetteh-Quarcoo, Simon K Attah, Eric S Donkor, Marian Nyako, Andrew A Minamor Emmanuel Afutu, Edward T Hervie, Patrick F, Ayeh-Kumi. ‘Urinary Schistosomiasis in Children—Still a Concern in Part of the Ghanaian Capital City’, Open Journal of Medical Microbiology, 2013;3:151-158. Available:https://doi.org/10.4236/ojmm.2013.33023.
Alemu A, Tegegne Y, Damte D, et al. Schistosoma mansoni and soil-transmitted helminths among preschool-aged children in Chuahit, Dembia district, Northwest Ethiopia: Prevalence, intensity of infection and associated risk factors. BMC Public Health. 2016;422. Available:https://doi.org/10.1186/s12889-016-2864-9
Geleta S, Alemu A, Getie S. Prevalence of urinary schistosomiasis and associated risk factors among Abobo Primary School children in Gambella Regional State, southwestern Ethiopia: A cross-sectional study. Parasites Vectors. 2015;8:215. Available:https://doi.org/10.1186/s13071-015-0822-5
Agnew-Blais J, Carnevale J, Gropper A, Shilika E, Bail R, Ngoma M. ‘Schistosomiasis Haematobium Prevalence and Risk Factors in a School-age Population of Peri-urban Lusaka, Zambia’. Journal of Tropical Pediatrics, 2010;56(4):247-253. Available:https://doi.org/10.1093/tropej/fmp106
Muhubiri Kabuyaya, Moses J Chimbari, Tawanda Manyangadze, Samson Mukaratirwa. ‘Schistosomiasis risk factors based on the infection status among school-going children in the Ndumo area, Mkhanyakude district, South Africa’, Southern African Journal of Infectious Disease. 2017;32(2):67–72. Available:https://doi.org/10.1080/23120053.2016.1266139
Gerito Augusto, Rassul Nalá, Verónica Casmo, Acácio Sabonete, Lourenço Mapaco, Judite Monteiro. ‘Geographic Distribution and Prevalence of Schistosomiasis and Soil-Transmitted Helminths among Schoolchildren in Mozambique’, The American Journal of Tropical Medicine and Hygiene. 2009;81(5):799–803. Available:https://doi.org/10.4269/ajtmh.2009.08-0344
Fulford AJC, Ouma JH, Kariuki HC, Thiongo FW. ‘Water contact observations in Kenyan communities endemic for schistosomiasis: methodology and patterns of behaviour’, Parasitology. 1996;113(3):223–241. Available:https://doi.org/10.1017/S0031182000082007
Hany Sady, Hesham M Al-Mekhlafi, Mohammed A K Mahdy, Yvonne A L Lim, Rohela Mahmud, Johari Surin. ‘Prevalence and Associated Factors of Schistosomiasis among Children in Yemen: Implications for an Effective Control Programme’, PLoS Neglected Tropical Diseases. 2013; 7(8):e2377. Available:https://doi.org/10.1371/journal.pntd.0002377
Atupele P Kapito-Tembo, Victor Mwapasa, Steven R Meshnick, Young Samanyika, Dan Banda, Cameron Bowie, Sarah Radke. ‘Prevalence Distribution and Risk Factors for Schistosoma hematobium Infection among School Children in Blantyre, Malawi’, PLoS Neglected Tropical Diseases. 2009;3(1):e361. Available:https://doi.org/10.1371/journal.pntd.0000361
Kumbu RK, Makola KM, Bin L. ‘Prevalence of Schistosoma mansoni Infection in Four Health Areas of Kisantu Health Zone, Democratic Republic of the Congo’, Hindawi- Advances in Medicine. 2016;5. Available:https://doi.org/10.1155/2016/6596095
Satayathum SA, Muchiri EM, Ouma JH, Whalen CC, King CH. ‘Factors affecting infection or re-infection with Schistosoma haematobium in Coastal Kenya: Survival analysis during a nine-year,school-based treatment program’, American Journal of Tropical Medicine and Hygiene. 2006;75(1):83–92. Available:https://www.ncbi.nlm.nih.gov/pubmed/16837713
Pennance T, Person B, Muhsin MA, Khamis AN, Muhsin J, Khamis IS, Mohammed KA, Kabole F, Rollinson D Knopp S. Urogenital schistosomiasis transmission on Unguja Island, Zanzibar: characterisation of persistent hot-spots. Parasites & Vectors. 2016;9:646. Available:https://doi.org/10.1186/s13071-016-1847-0
Julie A Clennon, Charles H King, Eric M Muchiri, H Curtis Kariuki, John H Ouma, Peter Mungai, Uriel Kitron. ‘Spatial patterns of urinary schistosomiasis infection in a highly endemic area of coastal Kenya.’, The American Journal of Tropical Medicine and Hygiene. 2004;70(4):443–448. Available:https://doi.org/10.4269/ajtmh.2004.70.443
Mogeni P, Vandormael A, Cuadros D, Appleton C, Tanser F. Impact of community piped water coverage on re-infection with urogenital schistosomiasis in rural South Africa. eLife. 2020;9: e54012. Available:https://doi.org/10.7554/elife.54012
Sama MT, Oyono E, Ratard RC. High-risk behaviours and schistosomiasis infection in Kumba, South-West Province, Cameroon.’, International Journal of Environmental Research and Public Health. 2007;4(2): 101-105. Available:https://doi.org/10.3390/ijerph2007040003
Pinot De Moira, Fulford AJC, Kabatereine NB, Ouma JH, Booth M, Dunne DW. Analysis of Complex Patterns of Human Exposure and Immunity to Schistosomiasis mansoni: The Influence of Age, Sex, Ethnicity and IgE. PLOS Neglected Tropical Diseases. 2010;4(9): e820. Available:https://doi.org/10.1371/journal.pntd.0000820
Chaula SA, Tarimo DS. ‘Impact of praziquantel mass drug administration campaign on prevalence and intensity of Schistosoma haemamtobium among schoolchildren in Bahi district, Tanzania’, Tanzania Journal of Health Research. 2014;16(1). Available:https://doi.org/10.4314/thrb.v16i1.1
Tuhebwe D, Bagonza J, Ekirapa Kiracho E, Yeka A, Elliott AM, Nuwaha F. ‘Uptake of Mass Drug Administration Programme for Schistosomiasis Control in Koome Island, Central Uganda’, PloS ONE 2015;10(4):e0123673. Available:https://doi.org/10.1371/journal.pone.0123673