The Reliability of Some Biochemical and Haematological Parameters in Predicting Uncomplicated Malaria Parasite Infection among Children in Anambra State, Nigeria
International Journal of TROPICAL DISEASE & Health,
Page 45-52
DOI:
10.9734/ijtdh/2020/v41i2230411
Abstract
Malaria remains endemic in Sub-Saharan Africa. Haematological and biochemical changes that occur have been suggested as potential predictors of malaria. This study was aimed at evaluating the diagnostic relevance of some haematological and biochemical parameters in predicting malaria in children in Anambra State, Nigeria. A cross-sectional study involving 248 symptomatic and asymptomatic children in Anambra State, Nigeria was conducted. Thin blood films were prepared for each subject and stained with Giemsa to aid the detection of malaria parasites. Their haematological and biochemical parameters were determined. Haematological and biochemical parameters of infected and uninfected children from the communities and hospitals were compared using the Student’s t-test. Difference was set at p<0.05. Out of the 248 children, 46.3% infection was recorded in the community while in the hospital, the prevalence was 94.0%. In the community survey (household), infected children had higher mean value of SGOT, SGPT, total protein, bilirubin, total iron and PCV but the differences were not significant (p >0.05). The comparison of the biochemical and haematological indices, and the parasite density of infected and uninfected children from communities and hospitals in Anambra State, Nigeria showed that all the haematological indices except WBC of hospital and community infection did not differ significantly (p> 0.05), but there were significant differences in their Na+, total iron, SGPT and SGOT. The comparison of these results showed that the changes in serum levels of these parameters may not be associated with malaria infection.
Keywords:
- Biochemical
- haematological
- predicting
- malaria
- children.
How to Cite
References
Global Technical Strategy for malaria-2016-2030 The World Health Organization Geneva.
World Health Organization. World malaria report 2019. Geneva: World Health Organization; 2019. Licence: CC BY-NC-SA 3.0 IGO; 2019.
World Health Organization. World malaria report 2018. Geneva: World Health Organization; 2018. Licence: CC BY-NC-SA 3.0 IGO; 2018.
Available:https://www.severemal.. Severe Malaria Observatory. Nigeria.
Awoke, Arota. Profiles of haematological parameters in Plasmodium falciparum and Plasmodium vivax malaria patients attending Tercha General Hospital, Dawuro Zone, South Ethiopia.Infection and Drug Resistance. 2019;12: 521—527. DOI: http://dx.doi.org/10.17352/g
Gansan A, Ouedraogo IN, Henry NB, Soulama I, Ouedraogo E, Yaro JB, Darra A, Benjamin S, Konate AT, Tiono A, Sirima SB. Variation in haematological parameters in children less than five years of age with asymptomatic Plasmodium infection: implication for malaria field studies. Mem. Inst. OswaldoCruz. 2013; 108:5. Available:http://dx.doi.org/10.1590/0074-0276108052013017
Okeke OP, Imakwu CA, Eyo JE, Okafor FC. Effects of childhood malaria on the biochemical and haematological profiles of infected children in Anambra State, Nigeria. International Journal of Tropical Disease and Health. 2016;19(3):1-14.
Ali-Salahy M, Shnawa B, Abed A, Mandour A, Ali-Ezz A. Parasitaemia and its relation to haematological parameters and liver function among patients malaria in Abs, Hajjah, Northwest Yemen. Interdisciplinary perspective on Infectious Diseases. 2016; ID5954394. Available:https://do.org/10.1155/2016/5954394
Ministry of Lands and Survey, Awka. Map of Anambra State, Nigeria; 2010.
World Health Organization. Methods Manual: Microscopy for the detection, identification and quantification of malaria parasites on stained thick and thin blood film in research settings. WHO/TDR; 2016.
Sood R. Textbook of medical laboratory technology. First Edition. Jaypee Medical Publisher, New Delhi, India; 2006. Available:https://www.wwam.org...
Study Group plans to identify what determines white blood cell count during malaria infection.
Francis U, Isaac Z, Yakubu A, Enosakhare A, Felix E. Haematological of malaria infected patients in the University of Calabar Teaching Hospital, Calabar, Nigeria. Journal of Hematology and Thromboembolic Diseases. 2014;2:171. DOI: 10.4172/2329-8790.1000171
Available:https://i-base.info/guides/side/bilirubin-and-jaundice Increased bilirubin and jaundice (yellow skin and eyes) l Guides l HIV I-Base
Available:https://www.rxlist.com/consumer_chloramphenicol_chloramphenicol/drugs-condition.htm r(x)RxLIST
Drugs A-ZPill IdentifierSupplementsSymptom CheckerDiseasesDictionary . Available:https:www.ucsfbenioffchildrens.org/tests/003497.html
ALP (Alkaline Phosphatase) Isoenzyme l Medical Tests l UCSF Benioff Children’s Hospital.
Jairajpuri ZS, Rana S, Hassan MJ, Nabi F, Jetley S. An analysis of haematological parameter as a diagnostic test for malaria in patients with acute febrile illness: An institutional experience. Oman Medical Journal. 2014;29(1):12-17.
Haruna M, Sharif K, Larry FS, Abdul S, Christine N. How reliable arehaematological parameters in predicting uncomplicated Plasmodium falciparum malaria in anendemic region; 2013. Available:http://dx.doi.org/10.1155/2013/673798
Kotepui M, Piwkham D, PhunPhuech B, Phiwklam N, Chupeerach C, Duangmano S. Effects of malaria parasite density on blood cell parameters. PLoS One. 2015; 10(3):e0121057.
Gone T, Lemango F, Eliso E, Yohannes S, Yohannes T. The association between malaria and malnutrition among under-five children in Shashogo District, Southern Ethiopia: a case-control study. Infectious of Disease Poverty. 2017;6:9.
Das D, Grais RF, Okiro EA, Stepniewska K, Mansoor R, Van Der Kam S,Terlouw DJ, Tarning J,Barnes KI,Guerin PJ. Complex interactions between malaria and malnutrition: A systematic literature review. BMC Medicine. 2018;16:186.
Venugopal K, Hentzschel F, Valkiunas G. Plasmodium asexual growth and sexual development in the haemotopoietic niche of the host. Nt. REV. Microbiology.2020; 18:177–189.
Adamu J, Jigam AA. Effects of Malaria infection on some haematological and biochemical parameters in the general population and pregnant malaria patients attending two district hospitals in Niger State, Nigeria. Global Journal of Infectious Diseases and Clinical Research. 2019; 5(1):001-005. DOI: http://doi.org/10.17352/2455-5363.000021 Available:www.cancersupportcommunity.org
The Belmont Report: What is it and how does it relate to today’s clinical trials.
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