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Covid-19 is caused by the Betacoronavirus SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus-2) which is an enveloped RNA virus causing diseases in both humans and animals. This research involved a systematic review with the aid of computerised literature search from PubMed, Scopus, Medline, ScienceDirect, Embase and Google Scholar and other recently published editorials. Specific words/phrases used for the search included COVID-19 pandemic, COVID-19 vaccines development, SARS-CoV-2 and COVAX.The rapid velocity by which the virus spreads, based on its unexpectedly high infectivity, requires urgent action towards both the development of a vaccine and effective viral inhibitors to decrease the virulence or eliminate symptoms. The COVID-19 pandemic has caused marked effect on global health and the economy worldwide being that it is shrouded in numerous uncertainties as scientist worldwide are yet to fully understand the virus. Although significant progress have been recorded by scientists, new information of the virus keeps emerging especially with the emergence of new variants and the capability of the virus to infect a multitude organ types apart from the respiratory tract. Consequently, there is a need for scientists all over the world to be constantly updated with recent information evolving from current research. This review is a concise appraisal of the current status of the COVID-19 pandemic across various regions of the world.
Decaro N, Martella V, Saif LJ, Buonavoglia.COVID-19 from veterinary medicine and one health perspectives: What animal coronaviruses have taught us. 2020; Res in Vet Sci. 2020;131:21–23. Available:https://doi.org/10.1016/j.rvsc.2020.04.009.
Tomar A, Neeraj G. Prediction for the Spread of COVID-19 in India and Effectiveness of Preventive Measures. Sci of the Ttl Environ. 2020;728:138762, Available:https://doi.org/10.1016/j.scitotenv.2020.138762. CVR. COVID-19 in the U.S;2020. Assessed on 10th December, 2020. Accessed 31 January 2021. Available: https://coronavirus.jhu.edu/
Sokolovska L, Sultanova A, Cistjakovs M, Murovska M J. COVID-19: The third wave of coronavirus infection outbreak. Transl Sci. 2021;7:1-5. DOI: 10.15761/JTS.1000389.
WSJ. Coronavirus Variant in South Africa Sparks Fear of Faster Spread, Possible Reinfection; 2021. Accessed 3 February 2021. Available:https://www.wsj.com/articles/coronavirus-variant-in-south-africa-sparks-fear-of-faster-spread-possible-reinfection-11609358056
CDC. New COVID-19 variants; 2021. Accessed 3 February 2021. Available:https://www.cdc.gov/coronavirus/2019-ncov/transmission/variant.html
Nature. COVID research updates: COVID vaccines might lose potency against new viral variants; 2021. Accessed 3 February 2021. Available: https://doi.org/10.1038/d41586-020-00502-w
Taylor AP. The variant, called B.1.525, contains a worrisome mutation; 2021. Accessed 1 March 2021. Available: https://www.livescience.co m/ne w-coronavirus-variant-13-countries.html
Lephaka P. Parts of Africa grappling with COVID-19 second wave; 2021. Accessed 12 February 2021. Available:https://www.sabcnews.com/sabcnews/feature-parts-of-africa-grappling-with-covid-19-second-wave/
Reliefweb. Analyzing Africa’s Second Wave of COVID-19. 2021. Accessed 28 February 2021. Available:https://reliefweb.int/report/world/analyzing-africa-s-second-wave-covid-19
DW. Coronavirus: WHO warns of COVID-19 third wave, says Europe failed to learn from Asia; 2021. Accessed 12 February 2021. Available:https://www.dw.com/en/coronavirus-who-warns-of-covid-19-third-wave-says-europe-failed-to-learn-from-asia/a-55690325
Sabah D. WHO predicts 3rd wave of COVID-19 in Europe in early 2021. Accessed 12 February 2021. Available:https://www.dailysabah.com/world/europe/who-predicts-3rd-wave-of-covid-19-in-europe-in-early-2021
Koirala A, Joo YJ. Khatami A, Chiu C, Britton PN. Vaccines for COVID-19: The current state of play. Paediatr Respir Rev. 2020;35:43-49. DOI: 10.1016/j.prrv.2020.06.010.
Wang M, Cao R, Zhang L, Yang X, Liu J, Xu M. Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro. Cell Res; 2020. Available:https://doi.org/10.1038/s41422-020-0282-0.
Marc L, Natalie ED. Understanding COVID-19 vaccine efficacy. Science. 2021; 370(6518):763-765. DOI: 10.1126/science.abe5938
Kim JH, Marks F, Clemens JD. Looking beyond COVID-19 vaccine phase 3 trials. Nat Med. 2021;27:205–211. Available:https://doi.org/10.1038/s41591-021-01230-y
Lazarus JV, Ratzan SC, Palayew A. A global survey of potential acceptance of a COVID-19 vaccine. Nat Med; 2020. Available:https://doi.org/10.1038/s41591-020-1124-9
Koop A. Tracking COVID-19 Vaccines around the World; 2021. Accessed 12 February 2021. Available:https://www.visualcapitalist.com/tracking-covid-19-vaccines-around-the-world/.
Chung YH, Beiss V, Fiering SN, Steinmetz NF, Nano ACS. COVID-19 Vaccine Frontrunners and Their Nanotechnology. Design. 2020;14(10):12522-12537.
Mullard A. How COVID vaccines are being divided up around the world; 2021. Accessed 12 February 2021. Available:https://www.nature.com/articles/d41586-020-03370-6
Wu SC. Progress and Concept for COVID-19 Vaccine Development. Biotechnol J. 2020;15(6):e2000147. DOI:10.1002/biot.202000147
Okonjo-Iweala N. Globalising the Covid vaccine with WHO's Covax; 2021. Accessed 19 February 2021. Available:https://www.bangkokpost.com/opinion/opinion/2046899/globalising-the-covid-vaccine-with-whos-covax
Nature. Why a pioneering plan to distribute COVID vaccines equitably must succeed; 2021. Accessed 19 February 2021. Available:https://doi.org/10.1038/d41586-021-00044-9.
GAVI. COVID-19 vaccine doses shipped by the COVAX Facility head to Ghana, marking beginning of global roll-out. 2021. Accessed 1 March 2021. Available: https://www.gavi.org/live/covax-vaccine-roll-out FDA. COVID-19 Vaccine; 2021. Accessed 1 March 2021. Available: https://www.fda.gov/emergency-preparedness-and-response/coronavirus-disease-2019-covid-19/pfizer-biontech-covid-19-vaccinePfizer-BioNTech
Aljazeera. Which countries have rolled out COVID vaccine?; 2020. Accessed 1 March 2021. Available:https://www.aljazeera.com/news/2020/12/24/vaccine-rollout-which-countries-have-started
WHO. COVID-19 vaccines; 2021. Accessed 22 February 2021. Available:https://www.who.int/emergencies/diseases/novel-coronavirus-2019/covid-19-vaccines
Cyranoski D. Arab nations first to approve Chinese COVID vaccine — despite lack of public data; 2021. Accessed 27 February 2021. Available:https://www.nature.com/articles/d41586-020-03563-z
Ledford H. J&J’s one-shot COVID vaccine offers hope for faster protection.2021. Nature, Accessed 1st March 2021. Available:doi: https://doi.org/10.1038/d41586-021-00119-7
BBC. Johnson & Johnson COVID vaccine: FDA approves single-shot jab.2021 Accessed 1 March 2021. Available:https://www.bbc.com/news/world-us-canada-56226979
Wadman M. Could too much time between doses drive the coronavirus to outwit vaccines?; 2021. Accessed 1 March 2021. Available:https://www.sciencemag.org/news/2021/01/could-too-much-time-between-doses-drive-coronavirus-outwit-vaccines
BMJ. Covid-19 vaccination: What’s the evidence for extending the dosing interval? BMJ.2021;372. DOI: https://doi.org/10.1136/bmj.n18
Reuters. Corona vaccine; 2021. Accessed 27 February 2021. Available:https://www.reuters.com/article/health-coronavirus-vaccine-sinovac/sinovac-says-its-covid-19-vaccine-more-effective-with-longer-dosing-interval-idINKBN29N13R
Parkinson J. CDC modifies interval time between dosing for mrna-covid-19-vaccines to 6-weeks; 2021. Accessed 26 February 2021. Available:https://www.contagionlive.com/view/cdc-modifies-interval-time-between-dosing-for-mrna-covid-19-vaccines-to-6-weeks.
Ledford H. Could mixing COVID vaccines boost immune response? Nature; 2021. DOI: https://doi.org/10.1038/d41586-021-00315-5
Nature. COVID research updates: COVID vaccines might lose potency against new viral variants. Nature; 2021. DOI: https://doi.org/10.1038/d41586-020-00502-w
Bouadma L, Lescure FX, Lucet JC, Yazdanpanah Y, Timsit JF. Severe SARS-CoV-2 infections: practical considerations and management strategy for intensivists. Intensive Care Med. 2020;46(4):579– 582.
Stöhr K, Cox N. COVID-19 vaccines: call for global push to maintain efficacy Nature. 2021;590;36:. DOI: https://doi.org/10.1038/d41586-021-00273-y
CDC. Coronavirus disease. (COVID-19) Centers for Disease Control and Prevention; 2021. Accessed 27 February 2021. Available:https://www.cdc.gov/coronavirus/2019-ncov/index.html
Yamey G. Rich countries should tithe their vaccines Nature. 2021; 590:529. DOI: https://doi.org/10.1038/d41586-021-00470-9.
Holshue ML, DeBolt C, Lindquist S, Lofy KH, Wiesman J, Bruce H. First case of 2019 novel coronavirus in the United States. N Engl J Med; 2020. Available:https://doi.org/10.1056/NEJMoa2001191.