Cord Blood Haematological Profiling Study: Predictive Markers of Neonatal Health Status at Birth in Anyigba, North Central Nigeria
International Journal of TROPICAL DISEASE & Health,
Background: Neonatal mortality refers to the death of a live-born babies within the first 28 days of life remains a global public health challenge. Cord blood being the medium of communication, transmission of nutrients and wastes between mothers and fetus can reflect the health status of baby at birth if properly utilized. Owing to multiple factors involved in neonatal mortality, this study used umbilical cord blood haematological parameters to ascertain the health status of neonates at birth, the aim of this study is to use umbilical cord blood haematological parameters for management of neonates at birth.
Methodology: This research is a cross-sectional study carried out at the Departments of Obstetrics and Gynaecology and Medical Laboratory Department, Kogi State University Teaching Hospital, Anyigba, North Central Nigeria between January, and December, 2020. Cord blood from 164 babies delivered in Kogi State University Teaching Hospital, Grimard Catholic Hospital, and Amazing Grace Hospital between January and December, 2020 were analyzed for haematological parameters using Sysmex XP-300 automated haematology analyzer. The data obtained were expressed as mean ±standard deviation using SPSS statistical software, version 23.0. The indicator level of statistical significance was set at p<0.05.
Results: The results showed significant increase (p<0.05) of WBC, RBC, MCV, MCH and MCHC in unstable babies compared to the stable babies, significant decrease (p<0.05) in the platelets, neutrophil and mixed among unstable babies compared to the stable babies, but no significant difference in PCV, haemoglobin and lymphocyte counts of both stable and unstable babies. The results also demonstrated 25 deaths per 1000 live newborn neonates within 48hour during the period of study.
Conclusion: This study shows that cord blood haematological parameters at birth can be used to ascertain the health status of neonates.
- Neonatal mortality
- umbilical cord
- haematological parameters
- stable and unstable
How to Cite
UNICEF/WHO/World Bank/UN. Levels and trends in child mortality. UNICEF. New York, USA; 2015.
UNICEF, WHO, World Bank, United Nations. Levels and Trends in Child Mortality: report. United Nations Children’s Fund; 2014. Levels and Trends in Child Mortality: Report 2014.
UNICEF/WHO/Word Bank/UN. Levels and Trends in Child Mortality. New York, USA; 2012.
Lawn JE, Kinney MV, Black RE, Pitt C, Cousens S, Kerber K. Newborn survival: a multi-country analysis of a decade of change. Health Policy Plan. 2012;27:6– 28. Available:http://doi:10.1093/heapol/czs053
PLOS ONE | Available:https://doi.org/10.1371/journal.pone.0182990 August 9, 2017.
UNICEF/WHO/World Bank/UN. Levels and Trends in Child Mortality. USA; 2013.
Adeyele IT, Ofoegbu DI. Infant and Child Mortality in Nigeria: An Impact Analysis. 2015;3:122–32.
Cord Blood Information, Department of Pathology, Medical College of Wisconsin; 2013.
Pranke P, Failace RR, Allebrandt WF. Hematologic and immunophenotypic characterization of human umbilical cord blood. Acta Haematologica. 2001;105(2): 71–76.
Gupta, Ramesh Chandra 2007 Veterinary Toxicology basic and clinical principles Academic Press, ISBN 978 – 0 – 12 – 370467 – 2 Hirsh, Dwight.
Idemudia J, Bazuaye GN. Biochemical parameters of Umbilical Cord Blood in Niger Delta, Nigeria: Towards Ensuring Efficient Cord Blood Stem Cell Transplantation. International Journal of TROPICAL DISEASE & Health. 2013;3(4): 300-307. Available:https://doi.org/10.9734/IJTDH/2013/4759
Harvey. The Umbilical Cord. The Encyclopedia of Reproduction, Yale University School of Medicine; 2006.
Emmanuel IO, Obioma A, Blessing CD, et al. Determination of Haematological Changes Associated with Syphilis in Subjects in Umudike, Abia State, Nigeria. Cohesive J Microbiol Infect Dis. 2018;1(1): CJMI.000505.
Osaretin AT. Ebuehi, Oghenetega T. Oweh, Olufunke M. Ebuehi, Ayodeji A. Oluwole. Umbilical Cord Blood Plasmodium falciparum infection on Alkaline Phosphatase Activity, Serum Liver Enzymes and Blood Chemistry of Neonates. American Journal of Biochemistry. 2013;3(1):1-5.
Smith PB, Benjamin D. Clinical approach to the infected neonate. In: Long, S. Pickering, L. Prober, C. (eds). Principles and Practice of Pediatric Infectious Disease. Philadelphia, PA: Churchill Livingstone/Elsevier. 2008;530–539.
Pass R. Viral infections in the fetus and neonate. In: Long, S. Pickering, L. Prober, C. (eds). Principles and Practice of Pediatric Infectious Disease. Philadelphia, PA: Churchill Livingstone/Elsevier. 2008; 539–543.
Binh TQ, Suong NTB, Dinh NH, et al. Iron deficiency anemia in children with congenital heart disease and the usefulness of erythrocyte indexes as screening tool. Arch Gen Intern Med. 2018; 2(3):1-4.
Doig K, Zhang B. A methodical approach to interpreting the red blood cell parameters of the complete blood count. America Society of Clinical Laboratory Science. 2017;30(3):173-185.
Billig EM, McQueen PG, McKenzie FE. Foetal haemoglobin and the dynamics of paediatric malaria. Malar J. 2012;11:396.
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