Emerging Threat of Salmonella typhimurium in Extraintestinal Infections: Cases from a Tertiary Care Hospital in North India
Ashima Jain
Department of Microbiology and Serology, Artemis Hospital, Sector 51, Gurugram, Haryana, India.
Aparna Pandey *
Department of Microbiology and Serology, Artemis Hospital, Sector 51, Gurugram, Haryana, India.
Nirupama Chatterjee
Department of Education and Research Artemis Hospital, Sector 51, Gurugram, Haryana, India.
Santosh Kumar Giri
Department of Education and Research Artemis Hospital, Sector 51, Gurugram, Haryana, India.
Saurabh Anand
Department of Neurocritical Care and Neuroanaesthesia, Artemis Hospital, Sector 51, Gurugram, Haryana, India.
Ragesh Radhakrishnan Nair
Department of Hemato-Oncology and Bone Marrow Transplant, Artemis Hospital, Sector 51, Gurugram, Haryana, India.
Pawan Kumar Singh
Department of Hemato-Oncology and Bone Marrow Transplant, Artemis Hospital, Sector 51, Gurugram, Haryana, India.
Namita Jaggi
Department of Laboratory Medicine and Research, Artemis Hospital, Sector 51, Gurugram, Haryana, India.
*Author to whom correspondence should be addressed.
Abstract
Purpose: Infections due to invasive non-typhoid salmonella can be dangerous and fatal. The mode of infection and the severity varies from the typhoidal fevers. It is important to find the association between clinical features and the infecting serovar to understand the pathophysiology and course of treatment.
Methods: In the present study, extra-intestinal specimens (blood, cerebrospinal fluid and pus) from three patients suffering from septicaemia, meningitis and osteomyelitis were received. Micro-biological and biochemical test for species identification and antibiotic susceptibility was done as per standard protocol. Further, PCR based amplification and sequencing of a portion of the flagellin gene (FliC) was done to confirm the serovar.
Results: Salmonella enterica was identified from all the three by microbiological and biochemical examination.The sequence of the Flic gene confirmed the serovar to be S. typhimurium. All the patients were treated successfully for the infection by appropriate antibiotic therapy.
Conclusion: The study highlights that serovar Typhimurium is common in invasive non-typhoidal salmonellosis and its pathophysiology and virulence factors expression should be understood in various organ types for better treatment options and outcomes.
Keywords: Non-typhoidal salmonella, S. typhimurium, extra-intestinal infections, anti-microbial resistance.