International Journal of TROPICAL DISEASE & Health <p style="text-align: justify;"><strong>International Journal of TROPICAL DISEASE &amp; Health (IJTDH) (ISSN: 2278 – 1005)</strong> aims to publish&nbsp;high quality papers (<a href="/index.php/IJTDH/general-guideline-for-authors">Click here for Types of paper</a>)&nbsp;in the areas of tropical medicine and public health research, reports on the efficacy of new drugs and methods of treatment, prevention and control methodologies, new testing methods and equipment. This is a quality controlled, peer-reviewed, open access INTERNATIONAL journal. IJTDH will not only publish traditional full research reports, including short communications, but also this journal will publish reports/articles on all stages of the research process like study protocols, pilot studies and pre-protocols. IJTDH is novelty attracting, open minded, peer-reviewed medical periodical, designed to serve as a perfectly new platform for both mainstream and new ground shaking works as long as they are technically correct and scientifically motivated. This journal has no connection with any society or association, related to Tropical medicine, disease or Public health and allied fields. This is an independent journal run by SDI.</p> en-US (International Journal of TROPICAL DISEASE & Health) (International Journal of TROPICAL DISEASE & Health) Wed, 28 Apr 2021 10:00:01 +0000 OJS 60 Hepatitis C Virus Core Antigen for On-treatment Prediction of Sustained Virological Response to Direct Acting Antivirals in Chronic Hepatitis C <p><strong>Background and Aim:</strong> Cirrhotic patients have lower response rates to DAAs with increased frequency of adverse events. This study aims to evaluate the value of HCVcAg as an early predictor of SVR to DAAs in cirrhotic patients to justify the treatment and avoid side effects.</p> <p><strong>Patients and Methods:</strong> This prospective cohort study was conducted on 85 treatment-naive HCV cirrhotic patients who had fulfilled the inclusion and exclusion criteria of the National Treatment Protocol of chronic HCV infection. HCVcAg detection was done on 10<sup>th</sup> day of treatment. Predictivity of HCVcAg for SVR was assessed in terms of specificity, sensitivity, positive predictive value (PPV), negative predictive value (NPV) and accuracy rates. ROC curve was conducted to assess predictivity of HCVcAg as well.</p> <p><strong>Results:</strong> SVR12 was (91.76%). HCVcAg was negative in 79 patients; 78 of them achieved SVR, while it was positive in 6 patients; all of whom did not achieve SVR. HCVcAg had sensitivity, specificity, PPV, NPV and accuracy rates of 100%, 98.73%, 85.71%, 100% and 98.82% respectively in prediction of SVR. With AUC of 0.929. There was a positive strong significant correlation between HCVcAg and SVR12 (r = 0.898, P = 0.015).</p> <p><strong>Conclusion:</strong> HCVcAg is a sensitive, specific, accurate, easily available, and affordable on- treatment predictor of SVR in cirrhotic patients with chronic HCV with possible future treatment regimen modification to improve efficacy and tolerability in difficult to treat cirrhotic patients.</p> Sara Askar, Mahmoud Anees, Amal Elbendary, Abdelrahman Kobtan ##submission.copyrightStatement## Wed, 28 Apr 2021 10:01:03 +0000 Malaria and Intestinal Parasites among Children in Muslim Schools, Port Harcourt, Rivers State, Nigeria <p><strong>Introduction:</strong> Malaria and intestinal helminthes infections are major public health problem in low and middle-income countries affecting over 2 million people across the globe.</p> <p><strong>Objectives:</strong> This survey was carried out to determine the prevalence of malaria and intestinal parasites among Muslim school children in Port Harcourt, Rivers State.</p> <p><strong>Methodology:</strong> Four Muslim schools: kab model school Rumuagolu, Manbaul hikma Eliozu, An-nur school Rumuodomaya and Al-ameen school Eneka. One hundred and fifty (150) blood and stool samples were collected randomly from the pupils (70 males and 80 female; age range 5-12 years) and examined between the Months of May to July 2018.</p> <p><strong>Results:</strong> The overall prevalence of 50.7%, and 43.3% was recorded for malaria and intestinal helminthes respectively. The prevalence for malaria was 32.5%, 63.0%, 58.0% and 50.0%. Intestinal helminthes was 30%, 53.3%, 42.0% and 53.0% for kab, Manbaul hikma, An-nur and Al-ameen Schools respectively. The frequency of parasites encountered was as follows, <em>Strongyloides</em> <em>stercoralis</em> 8.7%, <em>Ascaris</em> <em>lumbricoides</em> 14.0%, <em>Enterobious</em> <em>vermicularis</em> 1.3%, <em>Necator</em> <em>americanus</em> 5.3%, <em>Ancylostoma</em> <em>duodenale</em> 4.7%, and <em>Trichuris</em> <em>trichuria</em> 9.3%. Malaria and intestinal helminthes infection was highest in females with 51.2% and 45.0% respectively. Pupils between ages 9-10 had the highest infection rate of (54.0%) for malaria while ages 7-8 had the highest prevalence of 47.7% for intestinal helminthes. Co-infection was 22.0%, 23.0%, 22.0% and 32.0% for kab, Manbaul hikma, An-nur and Al-ameen Schools Respectively.</p> <p><strong>Conclusions:</strong> The overall infection for malaria and intestinal helminthes was high. Therefore, regular de-worming of the pupils by parents, and health education are necessary to keep the prevalence in check. This study may also be used to predict risk for communities under consideration.</p> Eze, Chinwe Nwadiuto, Owhoeli Ovutor, Olasunkanmi, Rukayat Motunrayo ##submission.copyrightStatement## Wed, 28 Apr 2021 00:00:00 +0000 The Potential Risk of the Used Thaumatococcus danielli (Benn) Leaves in Food Packaging Process in Transmission of Antibiotic Resistant Pathogens in Ghana <p><em>Thaumatococcus danielli </em>leaf is a known forest plant species that is widely used by food vendors for food packaging. In this study, the possible risk of <em>T. danielli </em>leaf used in food packaging, with its antibiotic-resistant pathogen transmission potential was evaluated. Five hundred leaves were swabbed from vendors at different food joints and were subjected to the routine bacteriological examination. Pure cultures from swabs were biochemically analysed, after microscopic examination. Most bacteria isolates were members of the <em>Enterobacteriaceae</em>. Other species included<em> Staphylococcus aureus, </em>CoNS (Coagulase-Negative Staphylococci) and<em> Pseudomonas sp</em>. The bacterial isolates were tested for their antimicrobial susceptibility towards 11 antimicrobials. As well as some factors such as community hygiene levels and people behaviour and their influences on the transmission of these microorganisms were statistically analysed using frequency tables. Most of the food vendors (43%) were between the ages of 31-40. Those with tertiary education were mostly aware (58%) of the possible transmission of pathogens by the leaves. Moreover, the leaves are preferred by food buyers irrespective of their income. Bacteria belonging to sixteen (16) different genera were identified, all of which were resistant to at least three antibiotics. The study showed that <em>T. danielli</em> leaves used by food vendors in two popular markets in Cape Coast Metropolis were contaminated and may serve as a possible vehicle for antibiotic-resistant bacteria transmission.</p> Victoria Klutse, Samuel Addo Akwetey, Priscilla Abena Ankamaa Opare, Godwin Kwakye-Nuako ##submission.copyrightStatement## Tue, 04 May 2021 00:00:00 +0000